In August 2018 researchers from the USA published the results of their study to assess the association of coffee consumption with mortality, taking into consideration the genetic caffeine metabolism score (presence of the CYP1A2 genotype which makes individuals less effective at metabolizing caffeine). A total of 498,134 individuals from the UK (54% female, aged 38-73 years) who were not pregnant and for whom there was complete data on coffee intake and smoking status were involved in the study. 387,494 (78%) were coffee drinkers. Over a follow-up period of 10 years, 14,225 deaths occurred. Results showed that a higher coffee consumption was associated with reduced risk of dying early, including those drinking 8 or more cups per day and those with the gene indicating slower or faster caffeine metabolism.
Loftfield E et al. Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank. JAMA Intern Med. 2018 Aug 1;178(8):1086-1097.