Vitamin D and omega-3 fatty acid supplementation appears to significantly improve depression, anxiety and stress levels, reduces testosterone and inflammatory markers, and improve gene expression in women with polycystic ovary syndrome

In October 2018 researchers from Iran and Canada published the results of their study to assess the effect of vitamin D and omega-3 fatty acid supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. A total of 60 individuals, aged 18-40 years old, were divided into two equal groups, with one group taking 50,000 IU vitamin D every 2 weeks plus 2000 mg/day omega-3 fatty acid from fish oil and the second group a placebo for a 12-week period. Results showed that vitamin D and omega-3 fatty acid supplementation, compared with the placebo, significantly decreased testosterone levels. In addition, vitamin D and omega-3 fatty acid supplementation also improved depression, anxiety and stress levels and produced an increase in general health questionnaire scores. Vitamin D and omega-3 fatty acid supplementation was also associated with a significant reduction in inflammatory markers, a significant increase in total antioxidant capacity, and improvement in gene expression of interleukin-1 and vascular endothelial growth factor when compared with the placebo. 

Jamilian M et al. The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. J Affect Disord. 2018 Oct 1;238:32-38 

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