In October 2018 researchers from Iran and Canada published the results of their study to assess the effect of vitamin D and omega-3 fatty acid supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. A total of 60 individuals, aged 18-40 years old, were divided into two equal groups, with one group taking 50,000 IU vitamin D every 2 weeks plus 2000 mg/day omega-3 fatty acid from fish oil and the second group a placebo for a 12-week period. Results showed that vitamin D and omega-3 fatty acid supplementation, compared with the placebo, significantly decreased testosterone levels. In addition, vitamin D and omega-3 fatty acid supplementation also improved depression, anxiety and stress levels and produced an increase in general health questionnaire scores. Vitamin D and omega-3 fatty acid supplementation was also associated with a significant reduction in inflammatory markers, a significant increase in total antioxidant capacity, and improvement in gene expression of interleukin-1 and vascular endothelial growth factor when compared with the placebo.
Jamilian M et al. The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. J Affect Disord. 2018 Oct 1;238:32-38