In January 2019 researchers from Iran published the results of their study to assess the effect of vitamin D and probiotic supplementation on mental health, hormonal, inflammatory and stress levels in women with polycystic ovary syndrome. A total of 60 individuals, aged 18-40 years old, were divided into two equal groups with one group taking 50,000 IU vitamin D every 2 weeks plus 8 × 109 CFU/day probiotic and the second group a placebo for a 12-week period. Results showed that vitamin D and probiotic supplementation, compared with the placebo, significantly improved depression, anxiety and stress levels. In addition, general health questionnaire scores were higher in the vitamin D and probiotic supplementation group. Vitamin D and probiotic supplementation was also associated with a significant reduction in testosterone levels, hirsutism and inflammatory markers, and a significant increase in total antioxidant capacity, when compared with the placebo.
Ostadmohammadi V et al. Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome. J Ovarian Res. 2019 Jan 21;12(1):5