In April 2019 researchers from Iran published their review of the medical scientific literature to assess the effect of Coenzyme Q10 (CoQ10) supplementation on fatigue experienced by adolescents and adults. A total of 16 studies were included in their review. Results showed that CoQ10 supplementation was significantly beneficial in individuals with fibromyalgia, statin-related fatigue, multiple sclerosis and end-stage heart failure, as well as healthy individuals. A further analysis revealed that individuals with statin-related fatigue and fibromyalgia had better results than individuals in the other groups. Differences between study individuals should, however, be taken into account and further research is required.
Mehrabani S et al. Effect of coenzyme Q10 supplementation on fatigue: A systematic review of interventional studies. Complement Ther Med. 2019 Apr;43:181-187