In February 2019 researchers from Iran published the results of their study to assess the effect of vitamin D supplementation on anxiety, depression, and inflammation in women with diabetes type 2, vitamin D depression and anxiety. A total of 51 individuals, average age 47 years, received either 50,000 IU vitamin D3 (26 women) or a placebo (25 women) fortnightly for a period of 16 weeks. Sun exposure, dietary intake, depression, anxiety and stress scores plus inflammatory biomarkers (C-reactive protein and interleukin) were assessed at the start and end of the study. It should be noted that the assessment values were not significantly different between the groups. Results showed that anxiety levels significantly reduced in the vitamin D group when compared to the individuals receiving the placebo. It was also seen that those in the vitamin D group with lower vitamin D levels also had a significant reduction in their depression. A further analysis revealed that those receiving the vitamin D supplementation had a reduction in their C-reactive protein level and an increase in the interleukin level, thereby showing an improvement in their anti-inflammatory biomarkers.
Fazelian S et al. Effect of Vitamin D Supplement on Mood Status and Inflammation in Vitamin D Deficient Type 2 Diabetic Women with Anxiety: A Randomized Clinical Trial. Int J Prev Med. 2019 Feb 12;10:17